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Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Indeed, it does not only reduce the SA β-galactosidase activity, but it also reduces the progerin’s expression while preserving the expression of the normal form lamin A*.
Then, immunohistochemistry analysis of skin sections (ex vivo study) has proved thatMatrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure and tends to make ageing skin behave like young skin.